Continuous Processing Solutions

Pall has turned continuous bioprocessing theory into reality. Only Pall has the Continuous Ready products and integration expertise that has made Continuous Bioprocessing a reality. It enables bioprocessors to achieve the highest product quality, productivity and patient benefit with a dramatically smaller footprint and shorter lead times.    
   

Chromatography

Pall’s Cadence™ BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the Process Development (PD) laboratory to GMP Manufacturing.
Pall’s Cadence™ BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the Process Development (PD) laboratory to GMP Manufacturing.
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Featured Product: Cadence BioSMB Process System

The smaller footprint of the Cadence BioSMB System enables a significant reduction in sorbent requirements compared to a conventional chromatography system. Single-use technology is built into Cadence BioSMB Systems – including piping, pumps and a groundbreaking valve cassette – ensuring sanitary operation in harmony with strides forward in efficient set up and use. SMB technology provides much more effective use of sorbent and buffers. Cadence BioSMB Systems support multiple chromatographic processes, including capture and polishing with up to 8 columns to support multiple chromatographic processes for maximum flexibility in capture and polishing of the most demanding proteins.

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Clarification

The Cadence Acoustic Separator in conjunction with a polishing depth filter will continuously remove cells and cell debris from cell culture in a closed system, without the need for centrifugation or primary depth filtration.
The Cadence Acoustic Separator in conjunction with a polishing depth filter will continuously remove cells and cell debris from cell culture in a closed system, without the need for centrifugation or primary depth filtration.
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Featured Product: Cadence Acoustic Separator

Cells and particulates from the cell culture are continuously entrained by the standing acoustic wave of the Cadence Acoustic Separator, clarifying the cell culture from the bioreactor. The cell culture fluid passes unimpeded through the system and after a polishing step using a depth filter produces harvested cell culture fluid (HCCF) suitable for purification. 

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In-Line Concentration

Patented SPTFF (single pass tangential flow filtration) technology enables continuous concentration of the product.
Patented SPTFF (single pass tangential flow filtration) technology enables continuous concentration of the product.
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Featured Product: Cadence Inline Concentrator

The Cadence Inline Concentrator eliminates the requirement for re-circulation typically required for TFF, reducing shear damage and time for the processing step and improving quality of the process.    

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Game Changing Advances in Continuous Processing

Are you Continuous Ready?

Continuous manufacturing has been established in several processing industries for many years providing improved economics, quality and flexibility over batch manufacturing operations.
 
However, until recently the adoption of continuous approaches in bioprocessing has been limited to perfusion cell culture with downstream processing unit operations and formulation taking place in batch mode with associated capacity limitations and poor facility utilisation. Now, with the development of specific enabling continuous technology combined with the inherent benefits of single-use approaches it is possible for the biopharmaceutical industry embrace the continuous manufacturing paradigm and move towards integrated end to end continuous bioprocessing, resulting in a more efficient, agile and truly global production of biotherapeutics. Pall Life Sciences' Cadence™ continuous portfolio provides enabling technology for key unit operations for monoclonal antibodies and other recombinant proteins.

 

Cadence™ Acoustic Separator

Ideal for continuous removal of CHO cells and cell debris using a single-use acoustic chamber to achieve clarification of harvested cell culture fluid, ready for downstream processing.

Cadence™ BioSMB PD System

The first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the Process Development (PD) laboratory to GMP Manufacturing.

Cadence™ BioSMB Process System

The first disposable flow path continuous multi-column chromatography system designed for clinical manufacture under GMP, featuring 8 columns to enable process flexibility and efficiency.

Cadence™ Inline Concentrator

A holder-less single-pass tangential flow filtration device with a retentate flow restrictor. It can be implemented in biotech DSP processes for continuous processing or in-process volume reduction for savings in time and cost.

 

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