Continuous Processing Solutions

Pall has turned continuous bioprocessing theory into reality. Only Pall has the Continuous Ready products and integration expertise that has made Continuous Bioprocessing a reality. It enables bioprocessors to achieve the highest product quality, productivity and patient benefit with a dramatically smaller footprint and shorter lead times.    

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Chromatography

Pall’s Cadence BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the PD laboratory to GMP manufacturing.
Pall’s Cadence BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the PD laboratory to GMP manufacturing.
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Featured Product: Cadence BioSMB Process 350 System

The Cadence™ BioSMB Process 350 system’s single-use flow path helps to reduce costs and the risks of cleaning and cleaning validation. Its highly configurable valve block with eight column positions also enables continuous loading resulting in best productivity, and reduces time and cost in terms of facility usage, buffers and chromatography media. A modular design allows for hardware configuration for a wider range of flow rates, thus reducing CAPEX costs, storage space and maintenance. Plus its scalable design offers a proven route from process development to manufacturing scale, reducing tech transfer risk and delivering the benefits seen at development scale. 

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Clarification

The Cadence Acoustic Separator in conjunction with a polishing depth filter will continuously remove cells and cell debris from cell culture in a closed system, without the need for centrifugation or primary depth filtration.
The Cadence Acoustic Separator in conjunction with a polishing depth filter will continuously remove cells and cell debris from cell culture in a closed system, without the need for centrifugation or primary depth filtration.
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Featured Product: Cadence Acoustic Separator

Cells and particulates from the cell culture are continuously entrained by the standing acoustic wave of the Cadence Acoustic Separator, clarifying the cell culture from the bioreactor. The cell culture fluid passes unimpeded through the system and after a polishing step using a depth filter produces harvested cell culture fluid (HCCF) suitable for purification. 

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In-Line Concentration

Patented SPTFF (single pass tangential flow filtration) technology enables continuous concentration of the product.
Patented SPTFF (single pass tangential flow filtration) technology enables continuous concentration of the product.
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Featured Product: Cadence Inline Concentrator

The Cadence Inline Concentrator eliminates the requirement for re-circulation typically required for TFF, reducing shear damage and time for the processing step and improving quality of the process.    

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Game Changing Advances in Continuous Processing

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